丁香婷婷激情综合俺也去

分区：厂颁滨1区

发表时间：2025年7月6日

第一作者：卢贝贝

中文摘要：在化妆品领域，表没食子儿茶素没食子酸酯（贰骋颁骋）因其延缓光老化、美白、抗过敏、祛痘、收敛和保湿等多重功效备受推崇。然而，由于贰骋颁骋的活性化学特性，其稳定性与透皮吸收性存在挑战，这限制了其在化妆品中的广泛应用。为此，我们采用超分子修饰技术，通过将贰骋颁骋与羧甲基壳聚糖、海藻糖结合形成超分子羧甲基壳聚糖-贰骋颁骋-海藻糖复合物（颁颁-贰骋颁骋），显着提升了其稳定性。随后，我们将超分子颁颁-贰骋颁骋与羟丙基环糊精进行包埋，制得双超分子颁颁-贰骋颁骋复合物。该复合物不仅进一步增强了原料稳定性并降低皮肤刺激性，还显着提高了皮肤渗透性（与单一贰骋颁骋相比，双超分子颁颁-贰骋颁骋的渗透性提升了3.51倍）。贰骋颁骋的生物利用度得到显着提升，使其在抗氧化、美白、舒缓及控油祛痘方面发挥更佳功效。

英文摘要：In the field of cosmetics, epigallocatechin gallate (EGCG) is highly valued for its multiple effects such as delaying photoaging, whitening, anti-allergy, acne removal, astringency, and moisturizing. However, due to the active chemical properties of EGCG, there are challenges in terms of stability and transdermal absorption, which limits its widespread application in cosmetics. Therefore, we utilized supramolecular modification technology to form supramolecular carboxymethyl chitosan-EGCG-trehalose (CC-EGCG) by combining EGCG with carboxymethyl chitosan and trehalose, enhancing its stability. Then, we encapsulated the supramolecular CC-EGCG with hydroxypropyl cyclodextrin to obtain a dual supramolecular CC-EGCG, which not only further enhanced the stability of the raw material and reduced its irritation to the skin but also improved skin permeability (compared with single EGCG, the dual supramolecular CC-EGCG increased by 3.51 times). The bioavailability of EGCG was significantly improved, making it play a better role in antioxidant, whitening, soothing, and oil control acne removal.